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KMID : 0882420130840050764
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Korean Journal of Medicine
2013 Volume.84 No. 5 p.764 ~ p.768
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Henoch-Shonlein Purpura in a Patient with Ankylosing Spondylitis after Infliximab Therapy
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Jung Woo-Jin
Nam Yoon-Jeong
Lee Seong-Geun
Kim Ji-Min
Song Margaret
Kim Moon-Bum
Kim Geun-Tae
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Abstract
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Tumor necrosis factor alpha (TNF-α) inhibitors are used widely to treat patients with active rheumatoid arthritis and ankylosing spondylitis (AS). Although various cutaneous reactions can occur as side effects of TNF-α inhibitors, systemic vasculitis requiring withdrawal of the agent and immunosuppressive drugs is rare. A 59-year-old male with AS who had been treated with infliximab for 60 months visited us with complaints of palpable purpura on both legs and severe abdominal pain. Abdominal computed tomography showed diffuse wall thickening of the proximal jejunum and ileum and a skin biopsy revealed leukocytoclastic vasculitis. The patient was diagnosed with Henoch-Schonlein purpura (HSP). Infliximab was discontinued and systemic steroid therapy at 0.5 mg/kg resulted in prompt resolution of the HSP. Here, we report the first case of HSP in a patient with AS after infliximab treatment.
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KEYWORD
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Ankylosing spondylitis, Henoch-Schonlein purpura, Tumor necrosis factor-alpha inhibitor
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